Relationship between preexisting anti-varicella-zoster virus (VZV) antibody and clinical VZV reactivation in hematopoietic stem cell transplantation recipients.
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| Abstract |
Reactivation of latent varicella-zoster virus (VZV), presenting as localized zoster or as disseminated infection, is a common and potentially serious complication in hematopoietic stem cell transplantation (HSCT) recipients. We retrospectively studied anti-VZV immunoglobulin G titers by the immune adherence hemagglutination method after HSCT and also studied VZV DNA by real-time PCR during clinical VZV reactivation using cryopreserved serum samples. No significant difference was found between anti-VZV titers in 13 patients with VZV infection (localized zoster in 11 patients and disseminated zoster in 2 patients) and in 13 subjects without VZV infection at each time point after HSCT. Preexisting anti-VZV titers of disseminated zoster cases tended to be lower than those of localized zoster cases (P=0.10). Serum VZV DNA copy numbers at the onset of disseminated zoster cases tended to be higher than those of localized zoster cases (P=0.09). A strong inverse correlation was found between preexisting anti-VZV titer and serum VZV DNA at onset (r=-0.90, P=0.006). In HSCT recipients, preexisting antibody does not prevent the development of VZV reactivation but may contribute to decreased viral load at onset, resulting in a mild clinical course.
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| Authors | Masahiro Onozawa, Satoshi Hashino, Mutsumi Takahata, Fumie Fujisawa, Takahito Kawamura, Masao Nakagawa, Kaoru Kahata, Takeshi Kondo, Shuichi Ota, Junji Tanaka, Masahiro Imamura, Masahiro Asaka |
| Journal | Journal of clinical microbiology (J Clin Microbiol) Vol. 44 Issue 12 Pg. 4441-3 (Dec 2006) ISSN: 0095-1137 [Print] United States |
| PMID | 17035500 (Publication Type: Journal Article) |
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