Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: Double-blind, multicenter, 6-week, parallel-group study in hypercholesterolemic patients (n = 2959). Patients were randomized based on stratification by low-density lipoprotein cholesterol ( LDL-C) levels to ezetimibe/ simvastatin or rosuvastatin, respectively, at the usual starting (10/20 or 10 mg/day), the next highest (10/40 or 20 mg/day), and maximum doses (10/80 or 40 mg/day). RESULTS: CONCLUSION:
Ezetimibe/ simvastatin was more effective than rosuvastatin in LDL-C lowering, and provided greater or comparable improvements in other lipid measures and hsCRP at the approved usual starting, next highest, and maximum doses in hypercholesterolemic patients. Although the doses compared in this study were not equivalent on a milligram basis, the results provide clinically relevant information regarding the use of these drugs for initial therapy and for subsequent use at higher doses when appropriate. Both treatments were generally well-tolerated; however, this study was not powered nor of sufficient duration to assess the prevalence of rare clinical adverse effects. Overall, ezetimibe/ simvastatin offers an effective and tolerable treatment option for lipid management. An assessment of its full clinical benefit awaits evaluation in longer-term clinical studies.
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Authors | Alberico L Catapano, Michael H Davidson, Christie M Ballantyne, William E Brady, Russell A Gazzara, Joanne E Tomassini, Andrew M Tershakovec |
Journal | Current medical research and opinion
(Curr Med Res Opin)
Vol. 22
Issue 10
Pg. 2041-53
(Oct 2006)
ISSN: 1473-4877 [Electronic] England |
PMID | 17022864
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticholesteremic Agents
- Azetidines
- Cholesterol, LDL
- Drug Combinations
- Ezetimibe, Simvastatin Drug Combination
- Fluorobenzenes
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Pyrimidines
- Sulfonamides
- Tablets
- Rosuvastatin Calcium
- Simvastatin
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Topics |
- Anticholesteremic Agents
(administration & dosage, therapeutic use)
- Azetidines
(administration & dosage, therapeutic use)
- Cholesterol, LDL
(blood)
- Double-Blind Method
- Drug Combinations
- Ezetimibe, Simvastatin Drug Combination
- Female
- Fluorobenzenes
(administration & dosage, therapeutic use)
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(administration & dosage, therapeutic use)
- Hypercholesterolemia
(blood, drug therapy)
- Male
- Middle Aged
- Pyrimidines
(administration & dosage, therapeutic use)
- Rosuvastatin Calcium
- Simvastatin
(administration & dosage, therapeutic use)
- Sulfonamides
(administration & dosage, therapeutic use)
- Tablets
|