[Evaluation of the antihypoxic activity of glycine and its phosphorylated derivative].

Abstract

The antihypoxant activity of glycine and its phosphorilated derivative AKF 90-7 in doses 1, 20, 50 and 100 mg/kg was studied. AKF 90-7 increases the survival of laboratory animals under the conditions of various hypoxia types. The antihypoxic effect of glycine was the same with the effect of AKF 90-7 in hystotoxic hypoxia, but absent on the model of hemic hypoxia and substantially lower than that of AKF 90-7 on the models of hypercapnic and hypobaric hypoxia.

• Authors: L M Makarova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2006 May-Jun Vol. 69 Issue 3 Pg. 71-3 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 16878506 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Glycine

Topics

• Animals
• Antioxidants (administration & dosage)
• Disease Models, Animal
• Drug Evaluation, Preclinical
• Glycine (administration & dosage, analogs & derivatives)
• Hypoxia (drug therapy)
• Mice
• Mice, Inbred CBA