Abstract | PURPOSE: Intestinal toxicity is important in the therapeutic use of radiation as well as in nontherapeutic radiation exposure scenarios. Enteric sensory nerves are critical for mucosal homeostasis and for an appropriate response to injury. This study assessed the role of the two major neuropeptides released by sensory nerves, calcitonin gene-related peptide (CGRP) and substance P, in the intestinal radiation response. EXPERIMENTAL DESIGN: RESULTS: CONCLUSIONS:
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Authors | Junru Wang, Xiaohua Qiu, Ashwini Kulkarni, Martin Hauer-Jensen |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 12
Issue 13
Pg. 4112-8
(Jul 01 2006)
ISSN: 1078-0432 [Print] United States |
PMID | 16818712
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Chemical References |
- Calcitonin Gene-Related Peptide Receptor Antagonists
- Neurokinin-1 Receptor Antagonists
- Peptide Fragments
- Piperidines
- Quinuclidines
- Receptors, Calcitonin Gene-Related Peptide
- Receptors, Neurokinin-1
- GR 73632
- SR 140333
- Substance P
- Calcitonin Gene-Related Peptide
- Adenosine
- N-((1S,trans)-2-hydroxycyclopentyl)adenosine
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Topics |
- Adenosine
(analogs & derivatives, pharmacology)
- Animals
- Calcitonin Gene-Related Peptide
(administration & dosage, genetics)
- Calcitonin Gene-Related Peptide Receptor Antagonists
- Disease Models, Animal
- Gene Expression Profiling
- Intestines
(drug effects, radiation effects)
- Male
- Multivariate Analysis
- Neurokinin-1 Receptor Antagonists
- Peptide Fragments
(pharmacology)
- Piperidines
(pharmacology)
- Quinuclidines
(pharmacology)
- Radiation Injuries, Experimental
(drug therapy)
- Rats
- Rats, Sprague-Dawley
- Receptors, Calcitonin Gene-Related Peptide
(agonists)
- Receptors, Neurokinin-1
(agonists)
- Reverse Transcriptase Polymerase Chain Reaction
(methods)
- Substance P
(administration & dosage, analogs & derivatives, genetics, pharmacology)
- X-Rays
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