Association of two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene with adenomyosis, endometriosis, and leiomyomata in Japanese women.

Abstract

OBJECTIVE:

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a nuclear hormone receptor that plays an important role in many diseases. This study investigated whether two polymorphisms (Pro12Ala in exon B and C161T in exon 6) of the PPAR-gamma2 gene are related to adenomyosis, endometriosis, or leiomyomata.

METHODS:

A total of 390 patients with adenomyosis, endometriosis, and/or leiomyomata were classified into four groups: 103 patients with adenomyosis (21 adenomyosis only and 82 adenomyosis with endometriosis and/or leiomyomata), 95 patients with endometriosis only, 100 patients with leiomyomata only, and 92 patients with endometriosis and leiomyomata.

RESULTS:

There was no association between distribution of genotype or allele frequencies for the PPAR-gamma Pro12Ala polymorphism and the presence of adenomyosis, endometriosis, and/or leiomyomata. However, compared with results for controls, the PPAR-gamma 161CC genotype and 161C allele frequencies were significantly increased in patients with adenomyosis (genotype: chi2 = 8.185, corrected P value [Pc] = .0169; allele: chi2 = 8.337, Pc = .0155) and in patients with endometriosis (genotype: chi2 = 6.748, Pc = .0375; allele: chi2 = 6.413, Pc = .0453).

CONCLUSION:

The results suggest that the PPAR-gamma 161CC genotype could be a genetic risk factor for adenomyosis and endometriosis, whereas the Pro12Ala polymorphism was not associated with these estrogen-dependent benign uterine diseases in a Japanese population.

• Authors: Miyo Kiyomizu, Jo Kitawaki, Hiroshi Obayashi, Mitsuhiro Ohta, Hisato Koshiba, Hiroaki Ishihara, Hideo Honjo
• Journal: Journal of the Society for Gynecologic Investigation (J Soc Gynecol Investig) Vol. 13 Issue 5 Pg. 372-7 (Jul 2006) ISSN: 1556-7117 [Electronic] United States
• PMID: 16725353 (Publication Type: Journal Article)

Chemical References

• PPAR gamma
• DNA

Topics

• DNA (blood)
• Endometriosis (genetics)
• Female
• Gene Frequency
• Genotype
• Humans
• Japan
• Leiomyoma (genetics)
• PPAR gamma (genetics)
• Polymorphism, Genetic
• Uterine Neoplasms (genetics)