[Clinical significance of anti-phosphatidylserine-prothrombin complex antibodies in antiphospholipid syndrome].

Abstract

We clarified the clinical significance of IgG anti-phosphatidylserine-prothrombin complex (PS-PT) antibodies in the antiphospholipid syndrome (APS). The study population consisted of 122 patients with SLE and lupus-like disease. IgG anti-PS-PT antibodies were detected in 44% of 59 patients according to the diagnostic criteria by Harris and Hughes. This frequency was significantly (p < 0.005) higher than the 14% seen in patients without APS. IgG anti-PS-PT antibodies were strongly (p < 0.005) associated with thrombosis. In addition, IgG anti-PS-PT antibodies were positive in 64% of IgG beta2-GPI dependent anti-cardiolipin antibody negative APS patients under the Sapporo criteria. The above findings indicate that IgG anti-PS-PT antibodies as well as beta2,-GPI dependent anti-cardiolipin antibodies should be examined in the diagnosis of APS.

• Authors: Junichi Kaburaki, Masataka Kuwana, Hideto Kameda, Tsutomu Takeuchi, Jun Okada, Masao Katayama, Shunji Yoshida, Yasuo Ikeda
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 46 Issue 1 Pg. 19-21 (Jan 2005) ISSN: 0485-1439 [Print] Japan
• PMID: 16708913 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Immunoglobulin G
• Phosphatidylserines
• Prothrombin

Topics

• Adult
• Antiphospholipid Syndrome (diagnosis, immunology)
• Autoantibodies (blood)
• Female
• Humans
• Immunoglobulin G (blood)
• Male
• Middle Aged
• Phosphatidylserines (immunology)
• Prothrombin (immunology)