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Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome)

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2256  relevant articles (33 outcomes, 159 trials/studies) found for this Disease

Description: The presence of antibodies directed against phospholipids (ANTIBODIES, ANTIPHOSPHOLIPID). The condition is associated with a variety of diseases, notably systemic lupus erythematosus and other connective tissue diseases, thrombopenia, and arterial or venous thromboses. In pregnancy it can cause abortion. Of the phospholipids, the cardiolipins show markedly elevated levels of anticardiolipin antibodies (ANTIBODIES, ANTICARDIOLIPIN). Present also are high levels of lupus anticoagulant (LUPUS COAGULATION INHIBITOR).

Also Known As:
Antiphospholipid Antibody Syndrome; Syndrome, Antiphospholipid; Syndrome, Antiphospholipid Antibody; Anti-Phospholipid Antibody Syndrome; Anti-Phospholipid Syndrome; Anti Phospholipid Antibody Syndrome; Anti Phospholipid Syndrome; Antibody Syndrome, Anti-Phospholipid; Antibody Syndrome, Antiphospholipid; Antiphospholipid Antibody Syndromes; Syndrome, Anti-Phospholipid; Syndrome, Anti-Phospholipid Antibody

Relationship Network

Disease Context: Research Results

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Immune System Diseases: 1237
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Autoimmune Diseases: 11588
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Antiphospholipid Syndrome: 2256

Related Diseases

1. Thrombosis (Thrombus)
2. Systemic Lupus Erythematosus (Libman-Sacks Disease)
3. Thrombocytopenia (Thrombopenia)
4. Venous Thrombosis (Deep-Vein Thrombosis)
5. Stroke (Strokes)

Experts

1. Shoenfeld, Y: 17 articles (06/2007 - 05/2000)
2. Shoenfeld, Yehuda: 11 articles (10/2008 - 03/2002)
3. Blank, M: 10 articles (06/2007 - 07/2000)
4. Merrill, Joan T: 9 articles (04/2008 - 03/2003)
5. Blank, Miri: 8 articles (05/2008 - 03/2002)
6. Chen, Pojen P: 7 articles (04/2008 - 03/2003)
7. Reshetniak, T M: 7 articles (01/2007 - 01/2002)
8. Khamashta, M A: 7 articles (09/2003 - 07/2000)
9. Ruffatti, A: 6 articles (10/2008 - 01/2001)
10. Pengo, V: 6 articles (10/2008 - 01/2001)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Antiphospholipid Syndrome:
1. Aspirin (Acetylsalicylic Acid)FDA LinkGeneric
2. Heparin (Liquaemin)FDA LinkGeneric
3. Warfarin (Coumadin)FDA LinkGeneric
4. Lupus Coagulation Inhibitor (Lupus Anticoagulant)IBA
5. Intravenous Immunoglobulins (IVIG)FDA Link
6. Antiphospholipid AntibodiesIBA
11/01/2008 - "OBJECTIVES: The purpose of this study was to obtain data on the association of antiphospholipid antibodies with clinical manifestations in childhood and to enable future studies to determine the impact of treatment and long-term outcome of pediatric antiphospholipid syndrome"
01/01/2008 - "A total cohort of 1000 patients with antiphospholipid syndrome (APS), derived from 13 countries (Belgium, Bulgaria, Denmark, France, Germany, Greece, Hungary, Israel, Italy, the Netherlands, Portugal, Spain and United Kingdom), has been followed since then by a European consortium that was created as part of the network promoted by the "European Forum on Antiphospholipid Antibodies", a study group devoted to the development of multicentre projects with large populations of APS patients"
11/01/2007 - "Over the past several years, studies have described the management of patients with key clinical manifestations of antiphospholipid antibodies, including patients with antiphospholipid antibody syndrome"
09/01/2007 - "RECENT FINDINGS: Limitations in the laboratory testing for antiphospholipid antibodies and changes in the diagnostic criteria for antiphospholipid antibody syndrome are important to recognize as they will affect the type of patients enrolled in the clinical trials evaluating antiphospholipid antibody syndrome therapies"
02/01/2007 - "OBJECTIVE: Studies that use a murine model of antiphospholipid syndrome have demonstrated a critical role for complement activation that leads to fetal and placental injury in the presence of antiphospholipid antibodies (APAs)"
Order ALL the reference details at left...
7. Anticardiolipin AntibodiesIBA
8. AnticoagulantsIBA
9. rituximab (Mabthera)FDA Link
10. Prednisolone (Predate)FDA LinkGeneric

Therapies and Procedures

1. Hormone Replacement Therapy (Therapy, Hormone Replacement)
10/01/2001 - "Generally accepted or "classically" acquired risk factors for venous thromboembolism include advanced age, prolonged immobilisation, surgery, fractures, use of oral contraceptives and hormone replacement therapy, pregnancy, puerperium, cancer and antiphospholipid syndrome"
02/20/1993 - "The 1st patient had repeated episodes of thrombosis on a background of altered general condition; he was examined by computed tomography (CT) which showed enlarged and presumably tumoral adrenal glands; adrenal insufficiency was present and improved under hormone replacement therapy; the thrombotic episodes were attributed to the antiphospholipid antibodies; after a 5-year follow-up the antiphospholipid syndrome remained alone, and further examinations showed progressive adrenal atrophy"
11/01/2001 - "The following order may be proposed: risk factors which cannot be changed: age (which remains the principal factor) and gender (women being at higher risk than men); true acquired risk factors such as cancer, dysimmune conditions (more specifically, the antiphospholipid syndrome) and hormone replacement therapy (oestroprogestative contraception which has been updated by the debate about "third generation pills" and the risk related to progesterone-like substances themselves; hormone replacement therapy of the menopause which still has no clinical trials to assess "our" forms with natural hormones administered transdermally or transmucosally)"
Order ALL the reference details at left...
2. Plasma Exchange
3. Plasmapheresis
4. Bone Marrow Transplantation (Transplantation, Bone Marrow)
5. Drug Therapy (Chemotherapy)

Best Treatments:
Research Summary Report
on Antiphospholipid Syndrome
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