Abstract |
Ehrlichia canis, a small obligately intracellular, tick-transmitted, gram-negative, alpha-proteobacterium, is the primary etiologic agent of globally distributed canine monocytic ehrlichiosis. Complete genome sequencing revealed that the E. canis genome consists of a single circular chromosome of 1,315,030 bp predicted to encode 925 proteins, 40 stable RNA species, 17 putative pseudogenes, and a substantial proportion of noncoding sequence (27%). Interesting genome features include a large set of proteins with transmembrane helices and/or signal sequences and a unique serine- threonine bias associated with the potential for O glycosylation that was prominent in proteins associated with pathogen-host interactions. Furthermore, two paralogous protein families associated with immune evasion were identified, one of which contains poly(G-C) tracts, suggesting that they may play a role in phase variation and facilitation of persistent infections. Genes associated with pathogen-host interactions were identified, including a small group encoding proteins (n = 12) with tandem repeats and another group encoding proteins with eukaryote-like ankyrin domains (n = 7).
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Authors | K Mavromatis, C Kuyler Doyle, A Lykidis, N Ivanova, M P Francino, P Chain, M Shin, S Malfatti, F Larimer, A Copeland, J C Detter, M Land, P M Richardson, X J Yu, D H Walker, J W McBride, N C Kyrpides |
Journal | Journal of bacteriology
(J Bacteriol)
Vol. 188
Issue 11
Pg. 4015-23
(Jun 2006)
ISSN: 0021-9193 [Print] United States |
PMID | 16707693
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Bacterial Proteins
- Glycoproteins
- RNA, Bacterial
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Topics |
- Animals
- Bacterial Proteins
(genetics)
- Dog Diseases
(microbiology)
- Dogs
- Ehrlichia canis
(classification, genetics, immunology, pathogenicity)
- Ehrlichiosis
(veterinary)
- Gene Expression Regulation, Bacterial
- Genome, Bacterial
- Glycoproteins
(genetics)
- Molecular Sequence Data
- Pseudogenes
- RNA, Bacterial
(genetics)
- Transcription, Genetic
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