Abstract | OBJECTIVES: BACKGROUND: METHODS: The study was embedded in the Rotterdam Study, a prospective population-based study among men and women aged 55 years and over. A total of 5,520 participants without history of coronary heart disease was genotyped for the Tyr402His polymorphism of the CFH gene. Cox proportional hazards analysis was used to determine risk of myocardial infarction for Tyr402His genotypes. RESULTS: Mean age among participants was 69.5 years (SD 9.1 years). The overall frequency of the His allele was 36%; genotype frequencies were 41%, 45%, and 14% for TyrTyr, TyrHis, and HisHis, respectively. During a mean follow-up period of 8.4 years, 226 myocardial infarctions occurred. After adjustment for age, gender, established cardiovascular risk factors, and CRP level, HisHis homozygotes had a hazard ratio of 1.77 (95% confidence interval 1.23 to 2.55) for myocardial infarction. Total cholesterol level, diabetes mellitus, and smoking modified the effect. The Tyr402His polymorphism was not associated with established cardiovascular risk factors or CRP level. CONCLUSIONS:
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Authors | Isabella Kardys, Caroline C W Klaver, Dominiek D G Despriet, Arthur A B Bergen, André G Uitterlinden, Albert Hofman, Ben A Oostra, Cornelia M Van Duijn, Paulus T V M de Jong, Jacqueline C M Witteman |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 47
Issue 8
Pg. 1568-75
(Apr 18 2006)
ISSN: 1558-3597 [Electronic] United States |
PMID | 16630992
(Publication Type: Journal Article)
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Chemical References |
- Tyrosine
- Histidine
- Complement Factor H
- Cholesterol
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Topics |
- Aged
- Cholesterol
(blood)
- Complement Factor H
(genetics)
- Diabetes Complications
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Histidine
- Homozygote
- Humans
- Incidence
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, etiology, genetics)
- Polymorphism, Genetic
- Proportional Hazards Models
- Risk Factors
- Smoking
(adverse effects)
- Tyrosine
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