Caspases leave the beaten track: caspase-mediated activation of NF-kappaB.

Abstract

The proteolytic activity of the cysteinyl aspartate-specific proteases, named caspases, mainly connotes their central role in apoptosis and inflammation. In this review we report on recent data on the role of caspases in the activation of nuclear factor kappaB (NF-kappaB), a transcription factor that fulfils a central role in innate and adaptive immunity, in cellular stress responses and in the induction of anti-apoptotic factors. Two different mechanisms by which caspases activate the NF-kappaB pathway are discussed.

• Authors: Mohamed Lamkanfi, Wim Declercq, Tom Vanden Berghe, Peter Vandenabeele
• Journal: The Journal of cell biology (J Cell Biol) Vol. 173 Issue 2 Pg. 165-71 (Apr 24 2006) ISSN: 0021-9525 [Print] United States
• PMID: 16618810 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• NF-kappa B
• Caspases

Topics

• Animals
• Caspases (physiology)
• Humans
• Mice
• Models, Biological
• NF-kappa B (metabolism)
• Signal Transduction
• Up-Regulation