Use of glargine and lente insulins in cats with diabetes mellitus.

Abstract

The goals of this study were to compare the efficacy of once-daily administered Glargine insulin to twice-daily administered Lente insulin in cats with diabetes mellitus and to describe the use of a high-protein, low-carbohydrate diet designed for the management of diabetes mellitus in cats. All cats with naturally occurring diabetes mellitus were eligible for inclusion. Baseline testing included a physical examination, serum biochemistry, urinalysis and urine culture, serum thyroxine concentration, and serum fructosamine concentration. All cats were fed the high-protein, low-carbohydrate diet exclusively. Cats were randomized to receive either 0.5 U/kg Lente insulin q12h or 0.5 U/kg Glargine insulin q24h. Re-evaluations were performed on all cats at weeks 1, 2, 4, 8, and 12, and included an assessment of clinical signs, physical examination, 16-hour blood glucose curve, and serum fructosamine concentrations. Thirteen cats completed the study (Lente, n = 7, Glargine, n = 6). There was significant improvement in serum fructosamine and glucose concentrations in all cats but there was no significant difference between the 2 insulin groups. Four of the 13 cats were in complete remission by the end of the study period (Lente, n = 3; Glargine, n = 1). The results of the study support the use of once-daily insulin Glargine or twice-daily Lente insulin in combination with a high-protein, low-carbohydrate diet for treatment of feline diabetes mellitus.

• Authors: Kelli E Weaver, Elizabeth A Rozanski, Orla M Mahony, Daniel L Chan, Lisa M Freeman
• Journal: Journal of veterinary internal medicine (J Vet Intern Med) 2006 Mar-Apr Vol. 20 Issue 2 Pg. 234-8 ISSN: 0891-6640 [Print] United States
• PMID: 16594577 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Hypoglycemic Agents
• Insulin
• Insulin, Long-Acting
• Insulin Glargine

Topics

• Animals
• Cat Diseases (drug therapy)
• Cats
• Diabetes Mellitus (drug therapy, veterinary)
• Diet
• Drug Administration Schedule (veterinary)
• Female
• Hypoglycemic Agents (therapeutic use)
• Insulin (analogs & derivatives, therapeutic use)
• Insulin Glargine
• Insulin, Long-Acting (therapeutic use)
• Male