Abstract | BACKGROUND: OBJECTIVES: SEARCH STRATEGY: SELECTION CRITERIA: We included case-control and cohort studies published in English that included at least 20 women with pre-eclampsia and that sampled serum or plasma TG at any time before, during or after pregnancy. DATA COLLECTION AND ANALYSIS: Mean maternal TG concentrations were compared between cases and controls within each study. The odds ratio of pre-eclampsia was calculated by comparing the risk of pre-eclampsia among women in each higher TG concentration category with that in the lowest reference category. MAIN RESULTS: A total of 19 case-control and 3 prospective cohort studies were included. In 14 studies, the mean TG concentration was significantly higher among pre-eclamptic cases than among unaffected controls; in seven other studies, there was a nonsignificant trend in the same direction. The risk of pre-eclampsia typically doubled with each increasing TG category. In the four studies that adjusted for potential confounders, such as maternal age, parity and body mass index, there was about a four-fold higher risk of pre-eclampsia in the highest relative to the lowest TG category. AUTHOR'S CONCLUSIONS:
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Authors | J G Ray, P Diamond, G Singh, C M Bell |
Journal | BJOG : an international journal of obstetrics and gynaecology
(BJOG)
Vol. 113
Issue 4
Pg. 379-86
(Apr 2006)
ISSN: 1470-0328 [Print] England |
PMID | 16553649
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Biomarkers
(blood)
- Case-Control Studies
- Cohort Studies
- Female
- Humans
- Hypertriglyceridemia
(blood, complications)
- Pre-Eclampsia
(blood, etiology)
- Pregnancy
- Risk Factors
- Triglycerides
(blood)
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