Abstract | BACKGROUND: It is known that endometriosis is an inflammatory disease and those patients seem to have lower pregnancy rates. The aim of the study was to investigate the concentrations of chemokines and proinflammatory cytokines in the follicular fluid of patients with and without endometriosis. METHODS: Follicular aspiration, recovering follicular fluid during assisted reproductive treatment, follicular fluid storage and analysis of chemokines and proinflammatory cytokines were carried out. Tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6, interleukin-8, interleukin-15, leukemia inhibitory factor, epithelial neutrophil-activating peptide 78, regulated upon activation, normal T-cell expressed and secreted, and growth-regulated oncogene-alpha were analyzed in the follicular fluid and compared between women with (n =47) and without endometriosis (n = 279). RESULTS: CONCLUSIONS:
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Authors | Dorothea M Wunder, Michael D Mueller, Martin H Birkhäuser, Nick A Bersinger |
Journal | Acta obstetricia et gynecologica Scandinavica
(Acta Obstet Gynecol Scand)
Vol. 85
Issue 3
Pg. 336-42
( 2006)
ISSN: 0001-6349 [Print] United States |
PMID | 16553183
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- CXCL5 protein, human
- Chemokine CXCL5
- Chemokines, CXC
- Interleukin-6
- Tumor Necrosis Factor-alpha
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Topics |
- Adult
- Biomarkers
(analysis)
- Chemokine CXCL5
- Chemokines, CXC
(analysis)
- Endometriosis
(diagnosis, pathology)
- Female
- Fertility
- Follicular Fluid
(immunology)
- Humans
- Interleukin-6
(analysis)
- Oocytes
- Ovarian Follicle
(physiology)
- Tumor Necrosis Factor-alpha
(analysis)
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