Increased plasma levels of IL-6 and IL-8 are associated with surgical site infection after pancreaticoduodenectomy.

Abstract

OBJECTIVES:

Cytokines and chemokines potentially modulate postoperative immune response. Association of circulating cytokines and chemokines with postoperative infectious complications after pancreaticoduodenectomy was evaluated.

METHODS:

Plasma concentrations of interleukin (IL) 6, IL-10, IL-8, macrophage chemoattractant protein 1, heat shock protein 70, and amylase, as well as amylase levels in peritoneal exudative fluid, were measured perioperatively in 60 consecutive patients who underwent pancreaticoduodenectomy.

RESULTS:

Of the 60 patients, 27 patients had surgical site infection (SSI), including peritoneal infection in all, intra-abdominal abscess in 14, and radiologically visualized pancreatic leakage in 6. Postoperative plasma levels of IL-6, IL-8, and macrophage chemoattractant protein 1, as well as peritoneal amylase levels, were significantly higher in patients with SSI than in those without SSI (P < 0.05). Nonpancreatic cancer as a histopathologic diagnosis, high pancreatic juice flow, and increased levels of IL-6 and IL-8 were independently associated with SSI (P < 0.05) in multiple logistic regression analysis. Plasma levels of IL-6 and IL-10 among patients with SSI were significantly higher in those with pancreatic leakage than in those without leakage.

CONCLUSIONS:

These results suggest that, in addition to pancreatic exocrine function, IL-6 and IL-8 are associated with postoperative SSI, including pancreatic leakage after pancreaticoduodenectomy.

• Authors: Fumio Kimura, Hiroaki Shimizu, Hiroyuki Yoshidome, Masayuki Ohtsuka, Atsushi Kato, Hideyuki Yoshitomi, Satoshi Nozawa, Katsunori Furukawa, Noboru Mitsuhashi, Shigeaki Sawada, Dan Takeuchi, Satoshi Ambiru, Masaru Miyazaki
• Journal: Pancreas (Pancreas) Vol. 32 Issue 2 Pg. 178-85 (Mar 2006) ISSN: 1536-4828 [Electronic] United States
• PMID: 16552338 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-6
• Interleukin-8

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Pancreatic Ductal (pathology, surgery)
• Duodenum (surgery)
• Female
• Humans
• Interleukin-6 (blood)
• Interleukin-8 (blood)
• Male
• Middle Aged
• Neoplasm Invasiveness
• Pancreatectomy (adverse effects)
• Pancreatic Neoplasms (pathology, surgery)
• Postoperative Complications (immunology)
• Surgical Wound Infection (epidemiology, immunology)