Neurotoxicity of acrylamide and its analogues and effects of these analogues and other agents on acrylamide neuropathy.

Abstract

N-Hydroxymethylacrylamide, N-methylacrylamide, and N,N-diethylacrylamide produce peripheral neuropathy in rats. Seven other compounds related to acrylamide do not produce neuropathy. Rats given one of the three neurotoxic compounds are more susceptible to acrylamide. A regime for testing acrylamide analogues for neuro-toxicity is suggested. DDT, phenobarbitone, or high dietary concentrations of vitamin A or E have no effect on the development of acrylamide neuropathy in rats. Acrylamide produces neuropathy in hens but not in frogs or goldfish.

• Authors: P M Edwards
• Journal: British journal of industrial medicine (Br J Ind Med) Vol. 32 Issue 1 Pg. 31-8 (Feb 1975) ISSN: 0007-1072 [Print] England
• PMID: 164879 (Publication Type: Journal Article)

Chemical References

• Acrylamides
• Vitamin A
• Vitamin E
• DDT
• Phenobarbital

Topics

• Acrylamides (toxicity)
• Animals
• Ataxia (chemically induced)
• Brachial Plexus (pathology)
• Chickens
• DDT (pharmacology)
• Female
• Goldfish
• Male
• Nerve Degeneration
• Peripheral Nervous System Diseases (chemically induced, pathology)
• Peroneal Nerve (pathology)
• Phenobarbital (pharmacology)
• Rana temporaria
• Rats
• Sciatic Nerve (pathology)
• Species Specificity
• Spinal Cord (pathology)
• Vitamin A (pharmacology)
• Vitamin E (pharmacology)