Efficacy of Helicobacter pylori eradication on the chronic mucosal inflammation of the remnant stomach after distal gastrectomy for early gastric cancer.

Abstract

Although eradication of Helicobacter pylori (Hp) after early gastric carcinoma has been recommended, very limited studies have been reported and the method differs from standard therapy. Here, we attempted the eradication of Hp in the remnant stomach after surgery for primary gastric cancer with the standardized method. We examined efficacy and the safeness of the treatment. Thirty-three H. pylori-positive patients after distal gastrectomy were treated with proton pump inhibitor (PPI)-based triple therapies. After eradication, endoscopic and histological changes were classified on the basis of the Updated Sydney System. The eradication rate in the remnant stomach was 90.9% (30 out of 33 cases) after triple therapy. Temporal minor side effects were notified in 3 cases. After eradication, the remnant stomach showed significant decreases in inflammation- and activity-scores. Moreover, significant improvement in glandular atrophy to normal mucosa was found. In conclusion, PPI-based standard therapy is just as effective for Hp eradication in the remnant stomach than it is in the non-operative stomach. Eradication therapy could be performed safely and resulted in a significant improvement in inflammation and atrophy of the mucosal layer in the remnant stomach after early gastric cancer surgery.

• Authors: N Onoda, K Katsuragi, T Sawada, K Maeda, A Mino, M Ohira, T Ishikawa, K Wakasa, K Hirakawa
• Journal: Journal of experimental & clinical cancer research : CR (J Exp Clin Cancer Res) Vol. 24 Issue 4 Pg. 515-21 (Dec 2005) ISSN: 0392-9078 [Print] England
• PMID: 16471313 (Publication Type: Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Infective Agents
• Anti-Ulcer Agents
• Benzimidazoles
• Metronidazole
• Rabeprazole
• Amoxicillin
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Adult
• Aged
• Amoxicillin (therapeutic use)
• Anti-Infective Agents (therapeutic use)
• Anti-Ulcer Agents (therapeutic use)
• Benzimidazoles (therapeutic use)
• Drug Therapy, Combination
• Endoscopy, Digestive System
• Female
• Gastrectomy
• Gastric Mucosa (drug effects, microbiology, pathology)
• Gastric Stump (pathology)
• Gastritis (drug therapy, microbiology, pathology)
• Helicobacter Infections (drug therapy)
• Helicobacter pylori
• Humans
• Male
• Metronidazole (therapeutic use)
• Middle Aged
• Omeprazole (analogs & derivatives, therapeutic use)
• Rabeprazole
• Stomach Neoplasms (pathology, surgery)