Abstract | OBJECTIVE: STUDY DESIGN: Patients surgically stage IB, IC and II endometrial cancer according to the International Federation of Gynecology and Obstetrics were enrolled in this study. Stage IIIA tumors with positive peritoneal cytology, in the absence of other evidence of extra uterine disease, were also included. RESULTS: One hundred and sixty-seven patients fulfilled the eligibility criteria and 58 patients (34.7%) underwent combination chemotherapy. Disease recurrence occurred in 10 patients within a median time of 17 months. Histologic grade 3 was an independent prognostic factor for both disease-free and overall survival rates. Fourteen of 23 patients with histologic grade 3 tumors received adjuvant chemotherapy consisting of cyclophosphamide (or etoposide), epirubicin and cisplatin (in 1989-1999) or paclitaxel, pirarubicin and carboplatin (in 2000-2002). The 5-year disease-free and overall survival rates for these individuals was 92.3%, a value significantly higher than those in patients who had not undergone chemotherapy (50.0%). CONCLUSIONS:
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Authors | Junichi Kodama, Noriko Seki, Yojiro Ojima, Keiichiro Nakamura, Atsushi Hongo, Yuji Hiramatsu |
Journal | European journal of obstetrics, gynecology, and reproductive biology
(Eur J Obstet Gynecol Reprod Biol)
Vol. 131
Issue 1
Pg. 76-80
(Mar 2007)
ISSN: 0301-2115 [Print] Ireland |
PMID | 16459012
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents
- Epirubicin
- Etoposide
- Cyclophosphamide
- Carboplatin
- Paclitaxel
- Cisplatin
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Agents
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Chemotherapy, Adjuvant
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage)
- Endometrial Neoplasms
(diagnosis, drug therapy, pathology)
- Epirubicin
(administration & dosage)
- Etoposide
(administration & dosage)
- Female
- Humans
- Middle Aged
- Neoplasm Staging
- Paclitaxel
(administration & dosage)
- Prognosis
- Treatment Outcome
- Uterus
(pathology)
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