The selective advantage of alpha1-antitrypsin deficiency.

Abstract

The S- and Z-deficiency alleles of alpha1-antitrypsin are found in more than 20% of some white populations. This high gene frequency suggests that these mutations confer a selective advantage, but the biologic mechanism of this has remained obscure. It is now well recognized that the S and Z alleles result in a conformational transition within the alpha1-antitrypsin molecule and the formation of polymers that are retained within the endoplasmic reticulum of hepatocytes. Polymers of mutant alpha1-antitrypsin can also form within the alveoli and small airways of the lung where they may drive the inflammation that underlies emphysema in individuals with alpha1-antitrypsin deficiency. This local production of polymers by mutant S and Z alpha1-antitrypsin may have also provided protection against infectious disease in the preantibiotic era by focusing and amplifying the inflammatory response to limit invasive respiratory and gastrointestinal infection. It is only since the discovery of antibiotics, the widespread adoption of smoking, and increased longevity that these protective, proinflammatory properties of alpha1-antitrypsin mutants have become detrimental to cause the emphysema and systemic inflammatory diseases associated with alpha1-antitrypsin deficiency.

• Authors: David A Lomas
• Journal: American journal of respiratory and critical care medicine (Am J Respir Crit Care Med) Vol. 173 Issue 10 Pg. 1072-7 (May 15 2006) ISSN: 1073-449X [Print] United States
• PMID: 16439713 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Polymers
• alpha 1-Antitrypsin

Topics

• Alleles
• Cells, Cultured
• Female
• Hepatocytes (cytology)
• Humans
• Inflammation (genetics, physiopathology)
• Liver Diseases (physiopathology)
• Male
• Pneumonia (physiopathology)
• Polymers
• Protein Conformation
• Protein Structure, Secondary
• Risk Factors
• Sensitivity and Specificity
• alpha 1-Antitrypsin (genetics, metabolism)
• alpha 1-Antitrypsin Deficiency (diagnosis, epidemiology, genetics)