High dose chemotherapy including paclitaxel (T-ICE) combined with peripheral blood stem cell transplantation for male germ cell tumor. Preliminary report.

Abstract

AIM:

To evaluate the feasibility and usefulness of high dose chemotherapy including paclitaxel (T-ICE) combined with peripheral blood stem cell transplantation (PBSCT) for male germ cell tumor.

METHODS:

Five male patients with advanced germ cell tumor underwent 1-6 courses of high dose chemotherapy including paclitaxel (T-ICE; 175 mg/m2 of paclitaxel, 1250 mg/m2 of carboplatin, 1500 mg/m2 of etoposide and 7.5 g/m2 of ifosfamide) with PBSCT after 2-3 courses of induction chemotherapy (PEB or VIP).

RESULTS:

In all patients, serum marker levels decreased to within the normal range by T-ICE. Two patients underwent resection of residual tumor. In one patient, viable cancer cells were detected in resected lymph node tissue and adjuvant chemotherapy was then performed. Although the follow-up period was short (7-15.5 months), four of the five patients (80%) showed no evidence of recurrent disease. No significant differences in side-effects were noted between T-ICE and conventional high dose ICE, which was previously performed in 39 patients at the Division of Urology, Kobe University Graduate School of Medicine, Japan.

CONCLUSIONS:

High dose chemotherapy, including T-ICE, combined with PBSCT showed an almost identical degree of side-effects as seen in previous high dose chemotherapy without paclitaxel. Although 80% of the patients showed no evidence of disease so far, the efficacy of T-ICE should be evaluated with more patients and longer follow up.

• Authors: Isao Hara, Yuji Yamada, Masafumi Kumano, Junya Furukawa, Kazuki Yamanaka, Masato Fujisawa
• Journal: International journal of urology : official journal of the Japanese Urological Association (Int J Urol) Vol. 12 Issue 12 Pg. 1074-8 (Dec 2005) ISSN: 0919-8172 [Print] Australia
• PMID: 16409617 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Paclitaxel

Topics

• Adult
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Combined Modality Therapy
• Feasibility Studies
• Humans
• Male
• Middle Aged
• Neoplasms, Germ Cell and Embryonal (therapy)
• Paclitaxel (administration & dosage)
• Peripheral Blood Stem Cell Transplantation
• Testicular Neoplasms (therapy)