Abstract | PURPOSE: We assessed in real-life practice the impact of age, cardiovascular comorbidity and co-medication on the tolerability and efficacy of 10 mg alfuzosin OD in men with lower urinary tract symptoms suggestive of benign prostatic obstruction. MATERIALS AND METHODS: RESULTS:
Alfuzosin was effective and well tolerated. Despite an increased prevalence of cardiovascular comorbidity and antihypertensive co-medication with age changes in blood pressure did not significantly differ among age groups. In controls, ie those with no cardiovascular comorbidity or co-medication, alfuzosin produced minimal decreases in sitting systolic (mean -2.6 to -2.8 mm Hg) and diastolic (mean -1.7 to -1.8 mm Hg) blood pressure. In men with cardiovascular comorbidity mean decreases in systolic (-3.5 to 5.8 mm Hg) and diastolic (-2.0 to -3.3 mm Hg) blood pressure remained marginal. Of the 6,523 exposed patients 19.3% withdrew from the study, mainly for adverse events (6.4%) or a lack of efficacy (5.3%), while 229 (3.5%) experienced serious adverse events and 1,558 (23.9%) reported at least 1 treatment emergent adverse event. The most commonly reported adverse event was dizziness/postural dizziness (4.8%). Hypotension/postural hypotension was uncommon (0.7%). Age, cardiovascular comorbidity and antihypertensive co-medication had no impact on the safety profile of 10 mg alfuzosin OD. CONCLUSIONS:
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Authors | R Hartung, H Matzkin, A Alcaraz, M Emberton, N Harving, J van Moorselaar, M Elhilali, G Vallancien, ALF-ONE Study Group |
Journal | The Journal of urology
(J Urol)
Vol. 175
Issue 2
Pg. 624-8; discussion 628
(Feb 2006)
ISSN: 0022-5347 [Print] United States |
PMID | 16407011
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic alpha-Antagonists
- Antihypertensive Agents
- Quinazolines
- alfuzosin
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Topics |
- Adrenergic alpha-Antagonists
(administration & dosage, adverse effects)
- Age Factors
- Aged
- Antihypertensive Agents
(therapeutic use)
- Cardiovascular Diseases
(complications)
- Diabetes Complications
(complications)
- Drug Administration Schedule
- Humans
- Hypertension
(complications, drug therapy)
- Male
- Middle Aged
- Myocardial Ischemia
(complications)
- Quinazolines
(administration & dosage, adverse effects)
- Urination Disorders
(complications, drug therapy)
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