Abstract | AIMS: METHODS AND RESULTS: We analysed 311 patients with mitral stenosis, compared with 175 non-valvular atrial fibrillation patients with prior embolism, stratified by a history of previous embolism and assigned to anticoagulant therapy [target international normalized ratio (INR) = 2.0-3.0] or combined antiplatelet plus moderate intensity anticoagulant therapy. Median follow-up was 2.9 years. Outcomes were fatal and non-fatal embolism, stroke and myocardial infarction, sudden death, and death from bleeding. Combined therapy in mitral stenosis patients, compared with anticoagulant alone therapy, reduced the risk of vascular events by 58.3%. During equal therapy, the outcome annual rates were essentially the same in non-valvular and valvular patients [hazard ratio 0.90 (95% confidence interval 0.37-2.16), P = 0.81]. During anticoagulant alone therapy, the annual event rate in mitral stenosis patients without prior embolism was low (2.5%) and it was very high in patients with prior embolism (6.6%). CONCLUSION:
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Authors | Francisco Pérez-Gómez, Antonio Salvador, Javier Zumalde, Jose A Iriarte, Jesús Berjón, Eduardo Alegría, Carlos Almería, Ramón Bover, Dionisio Herrera, Cristina Fernández |
Journal | European heart journal
(Eur Heart J)
Vol. 27
Issue 8
Pg. 960-7
(Apr 2006)
ISSN: 0195-668X [Print] England |
PMID | 16330464
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anticoagulants
- Drug Combinations
- Fibrinolytic Agents
- Platelet Aggregation Inhibitors
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Topics |
- Aged
- Anticoagulants
(therapeutic use)
- Atrial Fibrillation
(drug therapy)
- Death, Sudden, Cardiac
(etiology)
- Drug Combinations
- Embolism
(etiology)
- Female
- Fibrinolytic Agents
(therapeutic use)
- Hemorrhage
(etiology)
- Humans
- Male
- Mitral Valve Stenosis
(drug therapy)
- Myocardial Infarction
(etiology)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Risk Factors
- Stroke
(etiology)
- Treatment Outcome
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