Immunogenicity and reactogenicity of a reduced-antigen-content diphtheria-tetanus-acellular pertussis vaccine in healthy Taiwanese children and adolescents.

Abstract

PURPOSE:

Disease caused by Bordetella pertussis is increasingly being identified among older children and adults in immunized populations, indicating a waning of the vaccine-induced immunity. These findings suggest the need for booster immunization of older children and adults. Modern acellular reduced-antigen-content vaccines have been developed, which can be given as a booster in individuals more than 4 years of age. This study was to assess the immunogenicity and reactogenicity of Boostrix, GlaxoSmithKline Biologicals' reduced-antigen-content diphtheria-tetanus acellular pertussis (dTpa) vaccine, when administered as a booster in healthy subjects previously primed with DTP vaccine.

METHODS:

Healthy Taiwanese children and adolescents aged 6-8 years and 15-20 years, previously primed with DTP vaccine, were enrolled. All received one dose of Boostrix. Two blood samples were taken from each of them, one before vaccination and one at 1 month after vaccination. Serum antibodies to diphtheria and tetanus toxoids and immunoglobulin G (IgG) antibodies against the pertussis components PT, FHA and PRN were measured by enzyme-linked immunosorbent assay (ELISA) technique. Adverse reactions following vaccination were recorded.

RESULTS:

A total of 180 subjects were recruited. The vaccine response rates to the pertussis antigens ranged between 89.0-100%. There were no serious adverse events reported during the study period.

CONCLUSIONS:

The results of this study suggest that Boostrix may be safely and effectively administered as a booster dose to children previously primed with DTP vaccine.

• Authors: Li-Min Huang, Luan-Yin Chang, Haiwen Tang, Hans L Bock, Chun-Yi Lu, Fu-Yuan Huang, Tzou-Yien Lin, Chin-Yun Lee
• Journal: The Journal of adolescent health : official publication of the Society for Adolescent Medicine (J Adolesc Health) Vol. 37 Issue 6 Pg. 517 (Dec 2005) ISSN: 1879-1972 [Electronic] United States
• PMID: 16310132 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, Bacterial
• Boostrix
• Diphtheria-Tetanus-Pertussis Vaccine
• Immunoglobulin G

Topics

• Adolescent
• Adult
• Antibody Formation
• Antigens, Bacterial (immunology)
• Child
• Diphtheria-Tetanus-Pertussis Vaccine (adverse effects, immunology)
• Female
• Humans
• Immunization, Secondary
• Immunoglobulin G (analysis)
• Male
• Taiwan