Abstract | PURPOSE:
Chondrosarcoma is a malignant cartilaginous matrix-producing tumor that can be lethal in 10% to 50% of the patients. Surgery is the only effective treatment known as these tumors are notorious refractory to all types of conventional chemotherapy or radiotherapy. To identify a target for therapy, we want to determine whether estrogen signaling is active in chondrosarcoma because estrogen is important in the regulation of longitudinal growth that is initiated by chondrocyte proliferation and differentiation in the epiphyseal growth plate of long bones. EXPERIMENTAL DESIGN: RESULTS: CONCLUSIONS: These results show, on the RNA, protein, and cell biological levels, that the ligand and the receptor are active in estrogen-mediated signal transduction. This observation implicates potential use of targeted drugs that interfere with estrogen signaling, such as those applied for treating breast cancer.
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Authors | Anne-Marie Cleton-Jansen, Hetty M van Beerendonk, Hans J Baelde, Judith V G M Bovée, Marcel Karperien, Pancras C W Hogendoorn |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 11
Issue 22
Pg. 8028-35
(Nov 15 2005)
ISSN: 1078-0432 [Print] United States |
PMID | 16299232
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Androstadienes
- Aromatase Inhibitors
- Estrogen Antagonists
- Estrogens
- RNA, Messenger
- Receptors, Estrogen
- Androstenedione
- Aromatase
- exemestane
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Topics |
- Adult
- Aged
- Androstadienes
(pharmacology)
- Androstenedione
(pharmacology)
- Aromatase
(genetics, metabolism)
- Aromatase Inhibitors
(pharmacology)
- Bone Neoplasms
(drug therapy, genetics, pathology)
- Cell Line, Tumor
- Cell Proliferation
(drug effects)
- Chondrosarcoma
(drug therapy, genetics, pathology)
- Dose-Response Relationship, Drug
- Estrogen Antagonists
(therapeutic use)
- Estrogens
(pharmacology, physiology)
- Female
- Gene Expression Regulation, Neoplastic
(drug effects)
- Humans
- Male
- Middle Aged
- Neoplasm Metastasis
- RNA, Messenger
(genetics, metabolism)
- Receptors, Estrogen
(genetics, metabolism)
- Signal Transduction
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