Abstract | BACKGROUND: METHODS: In this case-control, cross-sectional study the frequency of the MTHFR 677C --> T and the 1298A --> C polymorphism was compared between patients with hypertension-related chronic renal failure (n = 90), patients with essential hypertension without kidney injury (n = 90), and healthy individuals (n = 90) who were matched for age and gender. In addition, the influence of these polymorphisms on homocysteine concentration in individuals with essential hypertension was examined. RESULTS: The frequency of the MTHFR 677 TT genotype did not differ between groups (4.5%, 12.3%, and 11.1%, respectively). Patients with hypertension and the 677TT genotype showed significantly higher homocysteine levels as compared to individuals having CC and CT. In the multivariate correlation analysis the MTHFR 677TT genotype (P < .01; beta = 0.27), age (P < .001; beta = 0.33), and body mass index (P < .01; beta = 0.3) were independent predictors for total homocysteine level. CONCLUSIONS:
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Authors | Leszek Tylicki, Manuela Födinger, Heidemarie Puttinger, Przemyslaw Rutkowski, Pawel Strozecki, Sylwia Tyszko, Boleslaw Rutkowski, Walter H Hörl |
Journal | American journal of hypertension
(Am J Hypertens)
Vol. 18
Issue 11
Pg. 1442-8
(Nov 2005)
ISSN: 0895-7061 [Print] United States |
PMID | 16280279
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Homocysteine
- Methylenetetrahydrofolate Reductase (NADPH2)
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Topics |
- Alleles
- Case-Control Studies
- Cross-Sectional Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease
(genetics)
- Genotype
- Homocysteine
(blood)
- Humans
- Hypertension
(complications, genetics, pathology)
- Kidney Failure, Chronic
(etiology)
- Male
- Methylenetetrahydrofolate Reductase (NADPH2)
(genetics)
- Middle Aged
- Multivariate Analysis
- Polymorphism, Single Nucleotide
- Predictive Value of Tests
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