Attenuation of renal ischemia-reperfusion injury by proanthocyanidin-rich extract from grape seeds.

Abstract

The effects of proanthocyanidin-rich extract in rats subjected to renal ischemia-reperfusion were examined. Proanthocyanidin-rich extract, which is prepared from grape seeds (Vitis vinifera L.), was given orally at doses of 5 and 10 mg/kg body weight/d for 20 consecutive days prior to ischemia-reperfusion. Administration of proanthocyanidin-rich extract attenuated renal dysfunction, as indicated by serum urea nitrogen and creatinine levels. Additionally, in the ischemic-reperfused kidneys, increased levels of thiobarbituric acid (TBA)-reactive substance and alterations of antioxidant enzyme activities such as superoxide dismutase, catalase and glutathione peroxidase (GSH-Px) were observed. Proanthocyanidin-rich extract-treated groups showed significantly reduced renal TBA-reactive substance levels and enhanced catalase and GSH-Px activities. These results suggest that proanthocyanidin-rich extract has protective effects against ischemia-reperfusion-induced renal damage associated with oxidative stress.

• Authors: Takako Nakagawa, Takako Yokozawa, Akiko Satoh, Hyun Young Kim
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 51 Issue 4 Pg. 283-6 (Aug 2005) ISSN: 0301-4800 [Print] Japan
• PMID: 16262003 (Publication Type: Journal Article)

Chemical References

• Plant Extracts
• Proanthocyanidins
• Thiobarbituric Acid Reactive Substances
• proanthocyanidin
• Catalase
• Glutathione Peroxidase
• Superoxide Dismutase

Topics

• Animals
• Catalase (metabolism)
• Glutathione Peroxidase (metabolism)
• Kidney (blood supply)
• Male
• Oxidative Stress
• Plant Extracts (administration & dosage)
• Proanthocyanidins (administration & dosage)
• Rats
• Rats, Wistar
• Reperfusion Injury (prevention & control)
• Seeds (chemistry)
• Superoxide Dismutase (metabolism)
• Thiobarbituric Acid Reactive Substances (analysis)
• Vitis (chemistry)