A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells.

Abstract

Memory CD8+ T cells can be divided into two subsets, central memory (T(CM)) and effector memory (T(EM)) CD8+ T cells. We found that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR superfamily, signaling is involved in differentiation of long-lived CD8+ T(CM) cells following Listeria monocytogenes infection. Although CD8+ T(EM) cells transiently accumulated in the nonlymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ T(CM) cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ T(EM) cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for T(CM) cells.

• Authors: Hitoshi Nishimura, Toshiki Yajima, Hiromi Muta, Eckhard R Podack, Kenzaburo Tani, Yasunobu Yoshikai
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 175 Issue 7 Pg. 4627-34 (Oct 01 2005) ISSN: 0022-1767 [Print] United States
• PMID: 16177108 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• CD30 Ligand
• Ccr7 protein, mouse
• Ki-1 Antigen
• Membrane Glycoproteins
• Receptors, CCR7
• Receptors, Chemokine
• Tnfsf8 protein, mouse

Topics

• Animals
• CD30 Ligand
• CD8-Positive T-Lymphocytes (cytology, immunology)
• Cell Differentiation (genetics, immunology)
• Cell Survival (genetics, immunology)
• Cells, Cultured
• Immunologic Memory (genetics)
• Ki-1 Antigen (physiology)
• Listeriosis (genetics, immunology)
• Membrane Glycoproteins (deficiency, genetics, physiology)
• Mice
• Mice, Inbred BALB C
• Mice, Knockout
• Receptors, CCR7
• Receptors, Chemokine (biosynthesis, genetics)
• Signal Transduction (genetics, immunology)
• T-Lymphocyte Subsets (cytology, immunology)