[Correlation analysis of increase in serum level of leptin with that of C reactive protein, troponin T and endothelin in patients with acute myocardial infarction].

Abstract

OBJECTIVE:

To determine serum leptin levels in patients with acute myocardial infarction (AMI) and coronary atherosclerosis (CS), and to analyze its correlation with C reactive protein (CRP), troponin T (TnT) and endothelin (ET).

METHODS:

Serum samples from confirmed AMI and CS patients were collected. Leptin and ET were assayed with high sensitive radioimmunoassay, TnT was determined with automatic biochemical analyser, and CRP was determined with enzyme-linked immunosorbant assay (ELISA).

RESULTS:

Compared with normal control group, serum leptin, TnT, CRP and ET levels increased significantly (all P<0.01) in AMI patients. Serum levels of other cytokines, except TnT in CS patients, increased significantly compared with normal control group (all P<0.01). Correlation analysis showed that all the changes were not correlated with each other, each being an independent factor. Only serum TnT levels of AMI and CS patients showed a significant difference (P<0.01).

CONCLUSION:

Serum leptin levels of both AMI and CS patients increase significantly without a significant difference between each other, and there is no correlation for leptin with CRP, TnT and ET.

• Authors: Guang-tao Yan, Hui Xue, Ji Lin, Xiu-hua Hao, Kai Zhang, Lu-huan Wang
• Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue (Zhongguo Wei Zhong Bing Ji Jiu Yi Xue) Vol. 17 Issue 9 Pg. 530-2 (Sep 2005) ISSN: 1003-0603 [Print] China
• PMID: 16146596 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Endothelins
• Leptin
• Troponin T
• C-Reactive Protein

Topics

• C-Reactive Protein (metabolism)
• Coronary Artery Disease (blood)
• Endothelins (blood)
• Humans
• Leptin (blood)
• Myocardial Infarction (blood)
• Troponin T (blood)