Abstract |
The aim of this study was to assess the implications of insulin resistance on the clinical and biochemical profiles of Korean type 2 diabetic patients. 122 patients with type 2 diabetes underwent a short insulin tolerance test to assess insulin resistance. Subjects were classified in tertiles according to ISI ( insulin sensitivity index), and the tertile I (the insulin- resistant group) and tertile III (the insulin-sensitive group) clinical and biochemical parameters were compared. Age, waist circumference (WC), systolic blood pressure (SBP), HbA1c, body fat content, and fasting plasma glucose were significantly higher in tertile I than tertile III (all p < 0.05). The frequency of hypertension and family history of cerebrovascular disease (CVD) were greater in tertile I than III (p < 0.05). To evaluate the factors affecting ISI, multiple regression was performed, and age, WC, SBP, HbA1c, and body fat content were found to be independently related to insulin resistance (p < 0.05). Old age, hypertension, central obesity, and poor glycemic control were identified as clinical parameters of insulin resistance in Korean type 2 diabetic patients.
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Authors | Jong-Suk Park, Chul-Sik Kim, Joo-Young Nam, Dol-Mi Kim, Min-Ho Jo, Jina Park, Chul-Woo Ahn, Bong-Soo Cha, Sung-Kil Lim, Kyung-Rae Kim, Hyun-Chul Lee, Kap-Bum Huh |
Journal | Yonsei medical journal
(Yonsei Med J)
Vol. 46
Issue 4
Pg. 484-90
(Aug 31 2005)
ISSN: 0513-5796 [Print] Korea (South) |
PMID | 16127772
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- C-Peptide
- Cholesterol, HDL
- Glycated Hemoglobin A
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Topics |
- Adult
- Aged
- Blood Glucose
(analysis)
- C-Peptide
(analysis)
- Cholesterol, HDL
(blood)
- Diabetes Mellitus, Type 2
(metabolism)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Insulin Resistance
- Male
- Middle Aged
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