Prednicarbate (Dermatop): profile of a corticosteroid.

Abstract

BACKGROUND:

Topical steroids have been a popular choice for treating various cutaneous disorders; however, the potential for significant local and systemic adverse events, like skin atrophy and hypothalamic-pituitary-adrenal (HPA) axis suppression, has limited their use.

OBJECTIVE:

This article reviews the topical steroid prednicarbate through its mechanism of action, clinical efficacy, and adverse events profile.

METHODS:

Published literature containing the word "prednicarbate" was examined and summarized.

RESULTS:

Prednicarbate is a nonhalogenated, double-ester derivative of prednisolone that has been used in the treatment of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses such as atopic dermatitis. It has a favorable benefit-risk ratio, low skin atrophy potential, and high anti-inflammatory action.

CONCLUSION:

These characteristics make prednicarbate an ideal alternative agent for children, elderly patients, and those who require long-term intermittent treatment.

• Authors: Aditya K Gupta, Melody Chow
• Journal: Journal of cutaneous medicine and surgery (J Cutan Med Surg) 2004 Jul-Aug Vol. 8 Issue 4 Pg. 244-7 ISSN: 1203-4754 [Print] United States
• PMID: 16092003 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids
• Prednisolone
• prednicarbate

Topics

• Administration, Topical
• Anti-Inflammatory Agents (adverse effects, pharmacology, therapeutic use)
• Dermatitis, Atopic (drug therapy)
• Glucocorticoids (adverse effects, pharmacology, therapeutic use)
• Humans
• Prednisolone (adverse effects, analogs & derivatives, pharmacology, therapeutic use)