Abstract | BACKGROUND: METHODS: RESULTS: We found that 73 out of 186 (39%) children developed hepatic veno-occlusive disease after transplantation. Multivariate analysis demonstrated that two factors significantly increased the risk of hepatic veno-occlusive disease occurrence: transfusion of platelet concentrates containing ABO-incompatible plasma (P=0.003) and use of melphalan in the conditioning regimen (P=0.006). Conversely, the number of platelet concentrates transfusions per week, child's age, weight, sex, and use of cyclophosphamide in the conditioning regimen had no effect. CONCLUSIONS: Transfusion of platelet concentrates containing ABO-incompatible plasma increases the risk of hepatic veno-occlusive disease in young children treated with a busulfan-containing regimen. Binding of A and/or B antigens expressed on the surface of hepatic endothelial cells may promote this complication. Transfusion of platelet concentrates containing ABO-incompatible plasma should be avoided in these children.
|
Authors | Valérie Lapierre, Cédric Mahé, Anne Aupérin, Férial Stambouli, Nadia Oubouzar, Dominique Tramalloni, Ellen Benhamou, Pierre Tiberghien, Olivier Hartmann |
Journal | Transplantation
(Transplantation)
Vol. 80
Issue 3
Pg. 314-9
(Aug 15 2005)
ISSN: 0041-1337 [Print] United States |
PMID | 16082325
(Publication Type: Journal Article)
|
Chemical References |
- ABO Blood-Group System
- Antineoplastic Agents
- Cyclophosphamide
- Busulfan
|
Topics |
- ABO Blood-Group System
- Adolescent
- Antineoplastic Agents
(adverse effects)
- Brain Neoplasms
(therapy)
- Busulfan
(pharmacology)
- Chemical and Drug Induced Liver Injury
- Child
- Child, Preschool
- Cyclophosphamide
(pharmacology)
- Female
- Follow-Up Studies
- Hematopoietic Stem Cell Transplantation
- Hepatic Veno-Occlusive Disease
(chemically induced, therapy)
- Humans
- Infant
- Liver Diseases
(therapy)
- Male
- Multivariate Analysis
- Neuroblastoma
(therapy)
- Platelet Transfusion
(methods)
- Proportional Hazards Models
- Risk Factors
- Time Factors
- Transplantation Conditioning
|