Abstract | BACKGROUND: OBJECTIVE: The objective was to compare the degree of response of plasma lipid concentrations and glycemic control to plant sterol consumption in a controlled diet between hypercholesterolemic type 2 diabetic and nondiabetic subjects. DESIGN: Fifteen nondiabetic subjects and 14 diabetic subjects participated in a double-blinded, randomized, crossover, placebo-controlled feeding trial. The diet included 1.8 g/d of either plant sterols or cornstarch placebo over 21 d, separated by a 28-d washout period. RESULTS:
Plant sterol consumption significantly reduced (P < 0.05) LDL-cholesterol concentrations from baseline in both nondiabetic and diabetic subjects by 15.1% and 26.8%, respectively. The diabetic subjects had significantly (P < 0.05) lower absolute concentrations of total cholesterol after treatment than did the nondiabetic subjects; however, there was no significant difference in the percentage change from the beginning to the end of the trial. There was also a significant decrease (P < 0.05) in absolute non- HDL-cholesterol concentrations after treatment in both groups. CONCLUSIONS:
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Authors | Vivian W Y Lau, Mélanie Journoud, Peter J H Jones |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 81
Issue 6
Pg. 1351-8
(Jun 2005)
ISSN: 0002-9165 [Print] United States |
PMID | 15941886
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Cholesterol, HDL
- Cholesterol, LDL
- Fatty Acids
- Glycated Hemoglobin A
- Insulin
- Phytosterols
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cross-Over Studies
- Diabetes Mellitus, Type 2
(blood, complications)
- Double-Blind Method
- Erythrocytes
(chemistry)
- Fatty Acids
(blood)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Hypercholesterolemia
(blood, drug therapy)
- Insulin
(metabolism)
- Male
- Middle Aged
- Phytosterols
(administration & dosage, metabolism, therapeutic use)
- Phytotherapy
- Treatment Outcome
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