Abstract | OBJECTIVE: METHODS AND RESULTS:
Atherosclerosis development was studied in 15 male and 15 female E3L/CRP mice; E3L transgenic littermates were used as controls. The mice were fed a hypercholesterolemic diet to induce atherosclerosis development. Cholesterol exposure did not differ between E3L/CRP and E3L mice. Plasma CRP levels were on average 10.2+/-6.5 mg/L in male E3L/CRP mice, 0.2+/-0.1 mg/L in female E3L/CRP mice, and undetectable in E3L mice. Quantification of atherosclerosis showed that lesion area in E3L/CRP mice was not different from that in E3L mice. CONCLUSIONS: This study demonstrates that mildly elevated levels of CRP in plasma do not contribute to the development of early atherosclerosis in hypercholesterolemic E3L/CRP mice.
|
Authors | A Trion, M P M de Maat, J W Jukema, A van der Laarse, M C Maas, E H Offerman, L M Havekes, A J Szalai, H M G Princen, J J Emeis |
Journal | Arteriosclerosis, thrombosis, and vascular biology
(Arterioscler Thromb Vasc Biol)
Vol. 25
Issue 8
Pg. 1635-40
(Aug 2005)
ISSN: 1524-4636 [Electronic] United States |
PMID | 15920036
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Apolipoprotein E3
- Apolipoproteins E
- Biomarkers
- C-Reactive Protein
- Cholesterol
|
Topics |
- Animals
- Apolipoprotein E3
- Apolipoproteins E
(genetics, metabolism)
- Atherosclerosis
(epidemiology, immunology, metabolism, pathology)
- Biomarkers
(metabolism)
- Body Weight
- C-Reactive Protein
(genetics, immunology, metabolism)
- Cholesterol
(blood)
- Early Diagnosis
- Eating
- Endothelium, Vascular
(immunology, metabolism, pathology)
- Female
- Humans
- Hypercholesterolemia
(epidemiology, immunology, metabolism, pathology)
- Male
- Mice
- Mice, Transgenic
- Monocytes
(pathology)
- Risk Factors
- Severity of Illness Index
|