Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells.

Abstract

BACKGROUND:

Myelosuppressives such as cyclophosphamide (Cy) and 5-fluorouracil (5FU), which can increase circulating CD34+ cells, may have a beneficial effect in the post-infarct heart.

METHODS AND RESULTS:

Twenty-four hours after 30-min ischemia-reperfusion, rabbits were intravenously treated with Cy (20 mg/kg), 5FU (15 mg/kg) or saline (S). Cy significantly improved cardiac function and remodeling and decreased the old infarct area 1 month after infarction, compared with those given S. The number of circulating CD34+ cells was higher and neovascularization and matrix metalloproteinase-1 was induced in the Cy group.

CONCLUSION:

Cy has potential for post-infarct treatment.

• Authors: Yu Misao, Masazumi Arai, Takamasa Ohno, Hiroaki Ushikoshi, Tomoyuki Takahashi, Genzou Takemura, Shinya Minatoguchi, Takako Fujiwara, Hisayoshi Fujiwara
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 69 Issue 6 Pg. 763-5 (Jun 2005) ISSN: 1346-9843 [Print] Japan
• PMID: 15914960 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD34
• Antineoplastic Agents, Alkylating
• Cyclophosphamide

Topics

• Animals
• Antigens, CD34 (blood)
• Antineoplastic Agents, Alkylating (administration & dosage)
• Cyclophosphamide (administration & dosage)
• Myocardial Reperfusion Injury (blood, drug therapy)
• Rabbits
• Recovery of Function (drug effects)