Abstract | OBJECTIVE: METHODS: RESULTS: Mean concentrations of the sex steroids adjusted for SHBG, and mean CAG repeat length did not differ significantly between the prostate cancer cases and controls. No significant associations with total prostate cancer were detected for plasma total testosterone concentration (comparing highest versus lowest quartiles: OR, 0.78; 95% CI, 0.48-1.28; P(trend) = 0.73) or the other sex hormones after adjusting for SHBG. However, plasma total testosterone concentration was positively associated with low-grade disease (Gleason sum < 7: OR, 1.91; 95% CI, 0.89-4.07; P(trend) = 0.02) and inversely associated with high-grade disease (Gleason sum > or = 7: OR, 0.26; 95% CI, 0.10-0.66; P(trend) = 0.01). Similar patterns for grade were observed for free testosterone. Short CAG repeat length was not associated with total prostate cancer (< or = 19 versus > or = 24: OR, 0.84; 95% CI, 0.57-1.23; P(trend) = 0.22) or grade of disease. No clear associations with regionally invasive or metastatic (> or = T3b, N1, or M1) were found for any of the hormones or the CAG repeat, although the number of these cases was small. CONCLUSIONS:
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Authors | Elizabeth A Platz, Michael F Leitzmann, Nader Rifai, Philip W Kantoff, Yen-Ching Chen, Meir J Stampfer, Walter C Willett, Edward Giovannucci |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 14
Issue 5
Pg. 1262-9
(May 2005)
ISSN: 1055-9965 [Print] United States |
PMID | 15894683
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Gonadal Steroid Hormones
- Receptors, Androgen
- Receptors, Cell Surface
- Sex Hormone-Binding Globulin
- sex hormone-binding globulin receptor
- Prostate-Specific Antigen
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Topics |
- Age Factors
- Aged
- Aged, 80 and over
- Case-Control Studies
- Genetic Predisposition to Disease
- Genotype
- Gonadal Steroid Hormones
(blood)
- Humans
- Incidence
- Logistic Models
- Male
- Middle Aged
- Neoplasm Staging
- Polymerase Chain Reaction
- Prostate-Specific Antigen
- Prostatic Neoplasms
(blood, epidemiology, genetics)
- Receptors, Androgen
(genetics)
- Receptors, Cell Surface
(genetics)
- Risk Factors
- Sex Hormone-Binding Globulin
(analysis)
- Surveys and Questionnaires
- United States
(epidemiology)
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