Abstract | BACKGROUND: The incidence of distal (corpus and antrum) gastric adenocarcinoma is decreasing with a simultaneous increase in incidence of proximal (cardia) adenocarcinoma. Epidemiological studies suggest that they may represent different diseases but corroborative molecular data are scarce. Intestinal metaplasia may have a lower malignant potential in the proximal stomach but regardless of the locations, its specificity as a predictor of carcinoma is low. AIMS: MATERIAL AND METHODS: Wax-embedded tissue from proximal and distal stomach including normal mucosa (n=86), intestinal metaplasia (n=83) and carcinoma (n=101) were used and slides were immunostained for human telomerase reverse transcriptase and pRb and scored semi-quantitatively. RESULTS: CONCLUSIONS:
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Authors | C Gulmann, S Lantuejoul, A Grace, M Leader, S Patchett, E Kay |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 37
Issue 6
Pg. 439-45
(Jun 2005)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 15893283
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- DNA-Binding Proteins
- Retinoblastoma Protein
- Telomerase
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Topics |
- Aged
- Biomarkers, Tumor
(metabolism)
- Carcinoma
(metabolism)
- DNA-Binding Proteins
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Intestinal Mucosa
(metabolism)
- Intestines
(pathology)
- Male
- Metaplasia
(metabolism)
- Middle Aged
- Precancerous Conditions
(metabolism)
- Retinoblastoma Protein
(metabolism)
- Stomach Neoplasms
(metabolism)
- Telomerase
(metabolism)
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