Differential expression of VEGF isoforms and VEGF receptors in cartilaginous tumors.

Abstract

Vascular endothelial growth factor (VEGF), which is known to have at least five isoforms and four receptors, is integral to tumor-induced neovascularization. In order to determine whether VEGF signaling is modulated in the development of cartilaginous tumors, we analyzed osteochondrogenic tumors for the expression of VEGF isoforms and VEGF receptors using the reverse transcription-polymerase chain reaction method. Although mRNA for VEGF121, VEGF165, VEGFR-1 and NRP-2 was widely expressed, mRNA expression for VEGF189, VEGFR-2 and NRP-1 was linked to a malignant phenotype such as local invasion. These results indicated that VEGF signaling was fine-tuned by the differential expression of the VEGF isoforms and VEGF receptors.

• Authors: Kiminori Yukata, Yoshito Matsui, Tomohiro Goto, Takahiro Kubo, Natsuo Yasui
• Journal: Anticancer research (Anticancer Res) 2005 Mar-Apr Vol. 25 Issue 2A Pg. 955-7 ISSN: 0250-7005 [Print] Greece
• PMID: 15868933 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Protein Isoforms
• RNA, Messenger
• Vascular Endothelial Growth Factor A
• Receptors, Vascular Endothelial Growth Factor

Topics

• Bone Neoplasms (genetics, metabolism)
• Chondroblastoma (genetics, metabolism)
• Chondrosarcoma (genetics, metabolism)
• Chondrosarcoma, Mesenchymal (genetics, metabolism)
• Fibroma (genetics, metabolism)
• Humans
• Neoplasms, Connective Tissue (genetics, metabolism)
• Osteochondroma (genetics, metabolism)
• Osteosarcoma (genetics, metabolism)
• Protein Isoforms
• RNA, Messenger (biosynthesis, genetics)
• Receptors, Vascular Endothelial Growth Factor (biosynthesis, genetics)
• Reverse Transcriptase Polymerase Chain Reaction
• Vascular Endothelial Growth Factor A (biosynthesis, genetics)