Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis.

Abstract

Milk kappa-casein-derived glycomacropeptide has immunomodulatory and bacterial toxin binding effects. The intestinal anti-inflammatory activity of glycomacropeptide was assessed in trinitrobenzenesulfonic acid-induced colitis in rats. Rats were administered glycomacropeptide daily starting either 2 d before (pretreatment) or 3 h after (post-treatment) colitis induction. Pretreatment with glycomacropeptide had a dose-dependent anti-inflammatory effect, characterized by lower body weight loss, decreased anorexia (57%), colonic damage (65%), and weight to length ratio (32%), as well as a reduction in colonic alkaline phosphatase activity (42%) and interleukin 1, trefoil factor 3, and inducible nitric oxide synthase mRNA levels (P < 0.05). The mechanism of action of glycomacropeptide is unknown but is consistent with an inhibition of the activation of immune cells. The magnitude of the anti-inflammatory effect was generally comparable to that of sulfasalazine, an established drug used in the treatment of inflammatory bowel disease. Bovine glycomacropeptide may play a role in the management of patients with inflammatory bowel disease.

• Authors: Abdelali Daddaoua, Víctor Puerta, Antonio Zarzuelo, María D Suárez, Fermín Sánchez de Medina, Olga Martínez-Augustin
• Journal: The Journal of nutrition (J Nutr) Vol. 135 Issue 5 Pg. 1164-70 (May 2005) ISSN: 0022-3166 [Print] United States
• PMID: 15867298 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• DNA Primers
• Glycopeptides
• Haptens
• Interleukin-1
• RNA, Messenger
• Trinitrobenzenesulfonic Acid

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Base Sequence
• Cattle
• Colitis (chemically induced, pathology, prevention & control)
• Colon (drug effects, pathology)
• DNA Primers
• Gene Expression Regulation (drug effects)
• Glycopeptides (therapeutic use)
• Haptens
• Interleukin-1 (genetics)
• Necrosis
• Polymerase Chain Reaction
• RNA, Messenger (genetics)
• Rats
• Trinitrobenzenesulfonic Acid