Modulation of cell proliferation and gene expression by alpha-tocopheryl phosphates: relevance to atherosclerosis and inflammation.

Abstract

The effect of a mixture of alpha-tocopheryl phosphate plus di-alpha-tocopheryl phosphate (TPm) was studied in vitro on two cell lines, RASMC (from rat aortic smooth muscle) and human THP-1 monocytic leukemia cells. Inhibition of cell proliferation by TPm was shown in both lines and occurred with TPm at concentrations lower than those at which alpha-tocopherol was equally inhibitory. TPm led in nonstimulated THP-1 cells to inhibition of CD36 mRNA and protein expression, to inhibition of oxidized low-density lipoprotein surface binding and oxLDL uptake. In nonstimulated THP-1 cells, alpha-tocopherol had only very weak effects on these events.

• Authors: Esra Ogru, Roksan Libinaki, Robert Gianello, Simon West, Adelina Munteanu, Jean-Marc Zingg, Angelo Azzi
• Journal: Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1031 Pg. 405-11 (Dec 2004) ISSN: 0077-8923 [Print] United States
• PMID: 15753182 (Publication Type: Journal Article)

Chemical References

• CD36 Antigens
• Lipoproteins, LDL
• oxidized low density lipoprotein
• alpha-tocopherol phosphate
• alpha-Tocopherol

Topics

• Animals
• Aorta
• Apoptosis (drug effects)
• Arteriosclerosis
• CD36 Antigens (genetics)
• Cell Division (drug effects)
• Cell Line
• Gene Expression (drug effects)
• Humans
• Inflammation
• Leukemia (pathology)
• Lipoproteins, LDL (metabolism)
• Muscle, Smooth, Vascular (cytology, drug effects)
• Rats
• Tumor Cells, Cultured
• alpha-Tocopherol (analogs & derivatives, pharmacology)