Abstract | BACKGROUND: METHODS: NT-pro-BNP was measured in baseline serum samples from 1034 patients referred for angiography because of symptoms or signs of coronary heart disease. The rate of death from all causes was determined after a median follow-up of nine years. RESULTS: At follow-up, 288 patients had died. The median NT-pro-BNP level was significantly lower among patients who survived than among those who died (120 pg per milliliter [interquartile range, 50 to 318] vs. 386 pg per milliliter [interquartile range, 146 to 897], P<0.001). Patients with NT-pro-BNP levels in the highest quartile were older, had a lower left ventricular ejection fraction (LVEF) and a lower creatinine clearance rate, and were more likely to have a history of myocardial infarction, clinically significant coronary artery disease, and diabetes than patients with NT-pro-BNP levels in the lowest quartile. In a multivariable Cox regression model, the hazard ratio for death from any cause for the patients with NT-pro-BNP levels in the fourth quartile as compared with those in the first quartile was 2.4 (95 percent confidence interval, 1.5 to 4.0; P<0.001); the NT-pro-BNP level added prognostic information beyond that provided by conventional risk factors, including the patient's age; sex; family history with respect to ischemic heart disease; the presence or absence of a history of myocardial infarction, angina, hypertension, diabetes, or chronic heart failure; creatinine clearance rate; body-mass index; smoking status; plasma lipid levels; LVEF; and the presence or absence of clinically significant coronary artery disease on angiography. CONCLUSIONS:
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Authors | Charlotte Kragelund, Bjørn Grønning, Lars Køber, Per Hildebrandt, Rolf Steffensen |
Journal | The New England journal of medicine
(N Engl J Med)
Vol. 352
Issue 7
Pg. 666-75
(Feb 17 2005)
ISSN: 1533-4406 [Electronic] United States |
PMID | 15716560
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright 2005 Massachusetts Medical Society. |
Chemical References |
- Biomarkers
- Nerve Tissue Proteins
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Aged
- Biomarkers
(blood)
- Cause of Death
- Coronary Angiography
- Coronary Disease
(blood, classification, diagnosis, mortality)
- Female
- Follow-Up Studies
- Gated Blood-Pool Imaging
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
- Nerve Tissue Proteins
(blood)
- Peptide Fragments
(blood)
- Prognosis
- Proportional Hazards Models
- Risk Factors
- Stroke Volume
- Survival Analysis
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