Abstract | BACKGROUND: METHODS: RESULTS: CONCLUSION: EP has a protective effect on hepatic I/R injury, mediated in part by decreasing lipid peroxidation, down-regulation of inflammatory mediators, and inhibition of apoptosis. Strategies using this additive to LR solution should be considered in clinical settings of ischemic liver injury to decrease organ damage.
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Authors | Allan Tsung, Takashi Kaizu, Atsunori Nakao, Lifang Shao, Brian Bucher, Mitchell P Fink, Noriko Murase, David A Geller |
Journal | Transplantation
(Transplantation)
Vol. 79
Issue 2
Pg. 196-204
(Jan 27 2005)
ISSN: 0041-1337 [Print] United States |
PMID | 15665768
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cytokines
- Pyruvates
- ethyl pyruvate
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Topics |
- Animals
- Apoptosis
(drug effects)
- Cytokines
(analysis)
- Lipid Peroxidation
(drug effects)
- Liver
(drug effects, pathology)
- Liver Circulation
- Liver Function Tests
- Male
- Necrosis
- Neutrophils
(drug effects, physiology)
- Pyruvates
(therapeutic use)
- Rats
- Rats, Inbred Lew
- Reperfusion Injury
(prevention & control)
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