Abstract | PURPOSE: EXPERIMENTAL DESIGN: Mutational analysis of the kinase domain of EGFR coding sequence was done on 101 fresh frozen tumor tissues from patients without prior gefitinib treatment and 16 paraffin-embedded tumor tissues from patients treated with gefitinib. Detection of phosphorylated EGFR by immunoblot was also done on frozen tumor tissues. RESULTS: CONCLUSIONS:
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Authors | Shiu-Feng Huang, Hui-Ping Liu, Ling-Hui Li, Yuan-Chieh Ku, Yu-Ning Fu, Hsien-Yu Tsai, Ya-Ting Chen, Yung-Feng Lin, Wen-Cheng Chang, Han-Pin Kuo, Yi-Cheng Wu, Yi-Rong Chen, Shih-Feng Tsai |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 10
Issue 24
Pg. 8195-203
(Dec 15 2004)
ISSN: 1078-0432 [Print] United States |
PMID | 15623594
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents
- Quinazolines
- ErbB Receptors
- Gefitinib
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Topics |
- Adenocarcinoma
(drug therapy, epidemiology, genetics)
- Adult
- Aged
- Aged, 80 and over
- Amino Acid Sequence
- Antineoplastic Agents
(therapeutic use)
- Base Sequence
- Carcinoma, Adenosquamous
(drug therapy, epidemiology, genetics)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, epidemiology, genetics)
- Carcinoma, Squamous Cell
(drug therapy, epidemiology, genetics)
- ErbB Receptors
(antagonists & inhibitors, genetics, metabolism)
- Female
- Gefitinib
- Humans
- Immunoblotting
- Lung Neoplasms
(drug therapy, epidemiology, genetics)
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation, Missense
(genetics)
- Phosphorylation
(drug effects)
- Quinazolines
(therapeutic use)
- Sequence Homology, Nucleic Acid
- Taiwan
(epidemiology)
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