Abstract | PURPOSE: EXPERIMENTAL DESIGN: RESULTS: The TS3'UTR 0bp/0bp genotype was associated with a significantly decreased risk of SCCHN [adjusted odd ratio (OR) = 0.67, 95% confidence interval (CI) = 0.47-0.94] compared with the 6bp/6bp genotype, but the TSER polymorphism had no main effect on risk of SCCHN. When we evaluated the two polymorphisms together by the number of protective alleles (the TSER 3R and TS3'UTR 0bp alleles), we found that the combined genotypes with four protective alleles (the TSER 3R3R and TS3'UTR 0bp/0bp) was associated with significantly decreased SCCHN risk (OR = 0.60, 95% CI = 0.37-0.98). In addition, the TS3'UTR 0bp genotypes were associated in an allele dose-dependent manner with a decreased risk of overall stage IV oral cancer (OR = 0.84, 95% CI = 0.52-1.34 for the 6bp/0bp genotype and OR = 0.26, 95% CI = 0.08-0.87 for the 0bp/0bp genotype; P(trend) = 0.035). CONCLUSION: The TSER and TS3'UTR polymorphisms are associated with SCCHN risk. The TSER 3R and TS3'UTR 0bp alleles seemed to jointly protect against SCCHN. In particular, the 0bp allele seemed to protect against oral cancer progression.
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Authors | Zhengdong Zhang, Qiuling Shi, Erich M Sturgis, Margaret R Spitz, Waun Ki Hong, Qingyi Wei |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 10
Issue 23
Pg. 7903-10
(Dec 01 2004)
ISSN: 1078-0432 [Print] United States |
PMID | 15585623
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- 3' Untranslated Regions
- 5' Untranslated Regions
- Thymidylate Synthase
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Topics |
- 3' Untranslated Regions
(genetics)
- 5' Untranslated Regions
(genetics)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Squamous Cell
(enzymology, genetics, pathology)
- Case-Control Studies
- Disease Progression
- Female
- Genetic Predisposition to Disease
- Genotype
- Head and Neck Neoplasms
(enzymology, genetics, pathology)
- Humans
- Male
- Middle Aged
- Polymorphism, Genetic
- Risk Factors
- Smoking
- Thymidylate Synthase
(genetics)
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