Abstract | BACKGROUND/AIMS:
NSAIDs induce gut damage throughout the entire gastrointestinal tract and bacterial translocation. The aim of this study was to examine if administration of glutamine was able to prevent the NSAID-induced gut damages and bacterial translocation in the animal models. METHODS: Rats were utilized into 5 groups; control group, diclofenac group, and diclofenac with glutamine 0.8, 1.6, and 3.2 g/kg/day group. The animals with glutamine were fed with L-glutamine for 4 days before diclofenac administration. Gut injury was induced by administration of a single dose of diclofenac (80 mg/kg orally). Intestinal permeability (24 hour urinary excretion of phenolsulfonphthalein), enteric aerobic bacterial counts, serum biochemical profiles and bacterial translocation to mesenteric lymph nodes, liver and spleen were measured. RESULTS: CONCLUSIONS:
Glutamine may have beneficial effects on NSAID-induced gut damage and bacterial translocation.
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Authors | Ji Yong Ann, Sang Jung Kim, Sang Pyo Han, Jeong Wook Kim, Hyung Joon Kim, Jae Hyuk Do, Jae Gyu Kim, Sae Kyung Chang, Woo Kyu Jeon |
Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
(Korean J Gastroenterol)
Vol. 44
Issue 5
Pg. 252-8
(Nov 2004)
ISSN: 1598-9992 [Print] Korea (South) |
PMID | 15564804
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Glutamine
- Diclofenac
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(pharmacology, toxicity)
- Bacterial Translocation
(drug effects)
- Diclofenac
(pharmacology, toxicity)
- Glutamine
(pharmacology)
- Intestines
(drug effects, microbiology)
- Male
- Rats
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