[Relationship between overexpression of the RIalpha subunit of the cAMP-dependent protein kinase and clinicopathological features of lung cancer].

Abstract

OBJECTIVE:

To explore the relationship between the overexpression of PKA RIalpha mRNA and cliniopathological parameters in lung cancer.

METHODS:

RT-PCR was used to detect the expression of PKA RIalpha mRNA in 54 cases with human lung cancer and matched normal tissues.

RESULTS:

(1) The expression of PKA RIalpha mRNA was significantly higher in cancer tissue (66.7%) than in normal tissues (20.4%) (P < 0.01). (2) The expression was significantly correlated with TNM stage (P < 0.01), being increased with TNM stage. (3) The expression was significantly higher in patients with positive lymph nodes than in those with negative lymph nodes (P < 0.01). (4) There were no significant associations of PKA RIalpha mRNA expression with histological type, differentiation grade or size of the tumor.

CONCLUSION:

This study indicates that the overexpression of PKA RIalpha mRNA may play an important role in the progression, metastasis and prognosis of lung cancer.

• Authors: Su-sheng Shi, Zu-gen He, Kang Shao, Fang Zhou, Mei-hua Xiong, Wei Huang, Ba-dong Mu, Cui-yan Zhang, Sen Zhang, Yun-tian Sun, Jie He
• Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology] (Zhonghua Zhong Liu Za Zhi) Vol. 26 Issue 9 Pg. 547-50 (Sep 2004) ISSN: 0253-3766 [Print] China
• PMID: 15555286 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
• PRKAR1A protein, human
• RNA, Messenger
• Cyclic AMP-Dependent Protein Kinases

Topics

• Adenocarcinoma (metabolism, secondary)
• Adult
• Aged
• Carcinoma, Squamous Cell (metabolism, secondary)
• Cyclic AMP-Dependent Protein Kinase RIalpha Subunit
• Cyclic AMP-Dependent Protein Kinases (biosynthesis, genetics)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Lung Neoplasms (metabolism, pathology)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Staging
• Prognosis
• RNA, Messenger (biosynthesis, genetics)