Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study.

Abstract

OBJECTIVE:

To assess the effects of soybean-derived pinitol on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus.

DESIGN:

Randomized, double-blind, placebo-controlled, parallel-group trial.

SETTING:

Pusan Paik Hospital, Pusan, Republic of Korea.

INTERVENTIONS:

A total of 30 patients with type II diabetes received an oral dose of 600 mg soybean-derived pinitol or placebo twice daily for 13 weeks.

RESULTS:

Pinitol significantly decreased mean fasting plasma glucose, insulin, fructosamine, HbA1c, and the homeostatic model assessment insulin resistance index (HOMA-IR, P<0.001). Pinitol significantly decreased total cholesterol, LDL-cholesterol, the LDL/HDL-cholesterol ratio, and systolic and diastolic blood pressure and increased HDL-cholesterol (P<0.05).

CONCLUSIONS:

These data suggest that soybean-derived pinitol may be beneficial in reducing cardiovascular risk in Korean type II diabetes.

• Authors: J-I Kim, J C Kim, M-J Kang, M-S Lee, J-J Kim, I-J Cha
• Journal: European journal of clinical nutrition (Eur J Clin Nutr) Vol. 59 Issue 3 Pg. 456-8 (Mar 2005) ISSN: 0954-3007 [Print] England
• PMID: 15536472 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Glycated Hemoglobin A
• Insulin
• pinitol
• Inositol
• Cholesterol

Topics

• Blood Glucose (drug effects, metabolism)
• Cardiovascular Diseases (blood, prevention & control)
• Cholesterol (blood, metabolism)
• Diabetes Mellitus, Type 2 (blood, drug therapy)
• Double-Blind Method
• Female
• Glycated Hemoglobin (metabolism)
• Humans
• Inositol (analogs & derivatives, therapeutic use)
• Insulin (metabolism)
• Male
• Middle Aged
• Risk Factors
• Soybeans (chemistry)