Liver transplantation-associated hypercalcemia followed by acute renal dysfunction.

Abstract

A 34-year-old woman with liver insufficiency due to glycogen storage disease III underwent a living spousal liver transplantation. Soon after the successful operation, moderate hypercalcemia along with hyperbilirubinemia emerged without clarified reasons. The hypercalcemia persisted for over a month despite calcitonin treatment and the serum calcium level surged to 13.2 mg/dl with albumin correction. Renal dysfunction was indicated by an acute increase in serum creatinine (approximately 0.8 to approximately 2.8 mg/ml), which was assumed to be hypercalcemia-induced and was effectively treated with bisphosphonate, pamidronate (30 mg, i.v.). Recent topics related to transplantation-associated hypercalcemia are discussed.

• Authors: Yuichi Shirasawa, Tomoyuki Nomura, Atsuhiro Yoshida, Takashi Hashimoto, Genjiro Kimura, Makoto Ito
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 43 Issue 9 Pg. 802-6 (Sep 2004) ISSN: 0918-2918 [Print] Japan
• PMID: 15497514 (Publication Type: Case Reports, Journal Article)

Topics

• Acute Kidney Injury (etiology)
• Adult
• Female
• Glycogen Storage Disease Type III (complications)
• Humans
• Hyperbilirubinemia (etiology)
• Hypercalcemia (drug therapy, etiology)
• Liver Failure (etiology, surgery)
• Liver Transplantation (adverse effects)
• Living Donors