Abstract |
The study sought to evaluate the response to cyclophosphamide (CPM) in hepatoblastoma (HB). Patients with a refractory or relapsing HB after first-line therapy as per SIOPEL 2 and 3 protocols were eligible. All patients were to receive two courses of CPM 2 g/m(2) on days 1 and 2 at 3-week intervals. Eighteen patients were included; 17 were evaluable for response. Prior treatment was cisplatinum alone (1 patient) or cisplatinum- carboplatin- doxorubicin (17 patients). The disease status at the beginning of CPM was: progressive during first-line treatment (10 patients), persistent unresectable disease at the end of the protocol (2 patients), relapse (6 patients). Tumour response was partial response (1 patient), stable disease (1 patient), progressive disease (15 patients) and not evaluable in one. All patients died, 17 of progressive disease and one of surgery complications. The low response rate (1/17) led the SIOPEL group to conclude that single-agent CPM is not effective for the treatment of relapsing or refractory HB.
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Authors | Walter Daniel Cacciavillano, Laurence Brugières, Margaret Childs, Elisabeth Shafford, Penelope Brock, Jon Pritchard, Rudolf Mailbach, Marcello Scopinaro, Giorgio Perilongo |
Journal | European journal of cancer (Oxford, England : 1990)
(Eur J Cancer)
Vol. 40
Issue 15
Pg. 2274-9
(Oct 2004)
ISSN: 0959-8049 [Print] England |
PMID | 15454253
(Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Alkylating
- Doxorubicin
- Cyclophosphamide
- Carboplatin
- Cisplatin
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Topics |
- Adolescent
- Adult
- Antineoplastic Agents, Alkylating
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Carboplatin
(administration & dosage)
- Child
- Child, Preschool
- Cisplatin
(administration & dosage)
- Cyclophosphamide
(administration & dosage, adverse effects)
- Doxorubicin
(administration & dosage)
- Female
- Hepatoblastoma
(drug therapy)
- Humans
- Liver Neoplasms
(drug therapy)
- Male
- Middle Aged
- Treatment Outcome
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