Abstract | OBJECTIVES: DESIGN: Cross-sectional study. SETTING: Outpatient clinic in Greve in Chianti and Bagno a Ripoli, Italy. PARTICIPANTS: A total of 597 subjects aged 65 to 93 without DM or dementia. MEASUREMENTS: RESULTS: IR (HOMA) was associated with longer TMT-B (correlation coefficient (r)=0.11; P=.006) and DIFF B-A times (r=0.10; P=.022). Subjects in the upper tertile of IR were older and had longer TMT-B and DIFF B-A than participants in the lowest tertile. After adjusting for age, sex, and years of formal education, IR was significantly correlated with TMT-A, TMT-B, and DIFF B-A. After adjusting for age, sex, education, body mass index, waist:hip girth ratio, HDL-C, triglycerides, IGF-1, hypertension, drug intake, and physical activity, the results did not significantly change. After introducing MMSE score into the model, IR continued to be an independent determinant of TMT-A (beta=11.005; P=.021), TMT-B (beta=28.379; P<.001), and DIFF B-A (beta=17.374; P=.011). CONCLUSION: IR is independently associated with frontal cortex function evidenced by poor TMT times in older persons without DM or dementia.
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Authors | Angela M Abbatecola, Giuseppe Paolisso, Marco Lamponi, Stefania Bandinelli, Fulvio Lauretani, Lenore Launer, Luigi Ferrucci |
Journal | Journal of the American Geriatrics Society
(J Am Geriatr Soc)
Vol. 52
Issue 10
Pg. 1713-8
(Oct 2004)
ISSN: 0002-8614 [Print] United States |
PMID | 15450050
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aging
(metabolism)
- Blood Glucose
- Cognition
- Cross-Sectional Studies
- Dementia
(diagnosis)
- Female
- Geriatric Assessment
(methods)
- Homeostasis
- Humans
- Insulin Resistance
- Italy
- Linear Models
- Male
- Middle Aged
- Trail Making Test
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