Hypoxia simultaneously inhibits endostatin production and stimulates vascular endothelial growth factor production by cultured human endometrial stromal cells.

Abstract

Hypoxia downregulated the concentration of endostatin in the culture media of human endometrial stromal cells but did not affect the messenger (m)RNA expression of collagen XVIII. Both mRNA and protein expression of vascular endothelial growth factor were upregulated in a hypoxic condition.

• Authors: Kaei Nasu, Masakazu Nishida, Junichiro Fukuda, Yasushi Kawano, Yoshihiro Nishida, Isao Miyakawa
• Journal: Fertility and sterility (Fertil Steril) Vol. 82 Issue 3 Pg. 756-9 (Sep 2004) ISSN: 0015-0282 [Print] United States
• PMID: 15374730 (Publication Type: Journal Article)

Chemical References

• Endostatins
• RNA, Messenger
• Vascular Endothelial Growth Factor A

Topics

• Adult
• Cell Hypoxia (physiology)
• Cells, Cultured
• Endometrium (pathology)
• Endostatins (genetics)
• Female
• Gene Expression Regulation (physiology)
• Humans
• Premenopause
• RNA, Messenger (genetics)
• Stromal Cells (physiology)
• Vascular Endothelial Growth Factor A (genetics)