NCX-701. NicOx.

Abstract

NicOx is developing NCX-701, a nitric oxide-releasing derivative of paracetamol (acetaminophen), for the potential treatment of inflammation and pain. The compound is currently undergoing phase III clinical trials.

• Authors: Girish P Joshi
• Journal: Current opinion in investigational drugs (London, England : 2000) (Curr Opin Investig Drugs) Vol. 5 Issue 7 Pg. 755-9 (Jul 2004) ISSN: 1472-4472 [Print] England
• PMID: 15298073 (Publication Type: Comparative Study, Evaluation Study, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drugs, Investigational
• Nitrates
• Acetaminophen
• 4-(nitroxy)butanoic acid 4-acetylaminophenyl ester

Topics

• Acetaminophen (analogs & derivatives, chemical synthesis, metabolism, pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage, metabolism, pharmacokinetics)
• Biological Availability
• Clinical Trials, Phase I as Topic
• Clinical Trials, Phase II as Topic
• Disease Models, Animal
• Drug Evaluation, Preclinical (methods)
• Drug Industry
• Drugs, Investigational
• Humans
• Mice
• Mice, Inbred BALB C
• Molecular Structure
• Nitrates (chemical synthesis, metabolism, pharmacology)
• Patents as Topic
• Randomized Controlled Trials as Topic
• Rats
• United States